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WHAT IS IT?
- A non-surgical tool to suppress appetite for sustained calorie restriction to get that weight off!
- A FDA approved medication for weight loss in obese and overweight individual with type 2 diabetes.
FOR WHO?
- Anyone who has seen their weight drift up (even as little as 8 pounds), who is having difficulty getting–and keeping–it off!
- People with a BMI of 20-30, normal weight to medically overweight.
- Otherwise healthy people with excess weight being their main medical problem.
HOW IT NATURALLY WORKS
- Semaglutide delays early postprandial (after eating) gastric emptying.
- Semaglutide decreases high blood glucose. This essentially stabilizes blood glucose levels and postprandial glucose levels.
- Semaglutide is a peptide [similar to natural GLP-1, glucagon-like peptide]. 94% of its sequence is similar to a naturally occurring peptide. It binds to your natural GLP-1 receptor. Small amino acid modifications enhance binding to the natural receptor and preserves its degradation–essentially enhancing its extended steady effect in your body.
- Tirzepatide is a similar class of drugs to semaglutide, but acts on two receptors (vs one for semaglutide). I view this as “bigger guns”, generally reserved for people with insulin resistance or resistant to semaglutide. It can more powerfully lower blood glucose. Most non-obese patients do not require this. Studies suggest greater weight loss with tirzepatide. However, is in patients with obesity, which is an inflammatory state. The metabolic effects on inflammation, on fatty liver, on the fat cell itself, and on insulin then come into play. Those individuals can really improve their health even beyond just weight loss.
HOW IT NATURALLY WORKS IN YOUR BODY
- Semaglutide will decrease your appetite by slowing stomach emptying. You will achieve satiety quicker resulting in eating and drinking less. This fullness will last longer, decreasing desire to eat again or consume more. Overall, your appetite will be lowered, less food and drink will be consumed, and decreased caloric intake in total.
- Maximum concentration of semaglutide is reached in 1-3 days. A steady state in the body is achieved after 4-5 weeks.
- Your dose will be adjusted based on your appetite suppression while minimizing discomfort.
- Taking the semaglutide in your abdomen, thigh, or upper arm doesn’t matter for the absorption. Change sites as you wish.
- Half of the semaglutide will be gone in about 1 week and will stay in your circulation for about 5 weeks after the last dose.
COMMON ADVERSE REACTIONS
- Nausea or feeling of acid reflux
- Constipation
- Diarrhea
- Abdominal pain
- Vomiting
Generally, if any of these reactions occur, they diminish over the first weeks. This is why I will slowly increase the dose to attain a maximum effect while diminishing adverse reactions.
Dr. Sharon Giese and her staff are happy to schedule a consultation with you about Elective Weight Loss. For more information on plastic surgery, testosterone therapy in NYC and Dr. Sharon Giese, please email us at ewl@sharongiesemd.com or call us at 212.421.3400.